Cover Image

Jaccoud’s arthropathy, an unusual manifestation of idiopathic retroperitoneal fibrosis: rapid improvement of symptoms after tocilizumab treatment

M. Benucci, A. Damiani, F. Li Gobbi, V. Grossi, M. Infantino, A. Arena, M. Manfredi
  • A. Damiani
    Rheumatology Unit, San Giovanni di Dio Hospital, Florence, Italy
  • F. Li Gobbi
    Rheumatology Unit, San Giovanni di Dio Hospital, Florence, Italy
  • V. Grossi
    Immunology and Allergology Laboratory, San Giovanni di Dio Hospital, Florence, Italy
  • M. Infantino
    Immunology and Allergology Laboratory, San Giovanni di Dio Hospital, Florence, Italy
  • A. Arena
    Nuclear Medicine, New Hospital, Prato, Italy
  • M. Manfredi
    Immunology and Allergology Laboratory, San Giovanni di Dio Hospital, Florence, Italy

Abstract

Jaccoud’s arthropathy (JA) is a chronic, non erosive, rheumatoid-like deformity associated with rheumatic fever (RF) and systemic lupus erythematosus and with other diseases such as psoriatic arthritis, connective tissue diseases, hypocomplementemic urticarial vasculitis, infections, sarcoidosis and neoplasia. We described a case of JA in a patient with cutaneous psoriasis but with a particular disease evolution associated with idiopathic retropritoneal fibrosis (IRF), evaluated with computed tomography, magnetic resonance and 18F-FDG PET/ CT. The patient, following failure with steroids, methotrexate and etanercept, was treated with tocilizumab (8 mg/kg) once every 4 weeks for 6 months. A rapid improvement of symptoms and disappearance of 18F-FDG uptake was shown. We describe a review of literature of rheumatic manifestations of IRF and the possible role of interleukin-6 in the pathway of JA and IRF.

Keywords

Jaccoud’s arthropathy; Idiopathic Retroperitoneal fibrosis; Tocilizumab.

Full Text:

PDF
Submitted: 2017-01-22 19:46:16
Published: 2017-08-03 15:30:45
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
189

Views:
PDF
54

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2017 M. Benucci, A. Damiani, F. Li Gobbi, V. Grossi, M. Infantino, A. Arena, M. Manfredi

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 
© PAGEPress 2008-2017     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185