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Successful treatment of refractory adult onset Still’s disease with rituximab

N. Belfeki, M. Smiti Khanfir, F. Said, A. Hamzaoui, T. Ben Salem, I. Ben Ghorbel, M. Lamloum, M.H. Houman
  • N. Belfeki
    Department of Internal Medicine, University Hospital of La Rabta, Tunis, Tunisia | belfeki.nabil@gmail.com
  • M. Smiti Khanfir
    Department of Internal Medicine, University Hospital of La Rabta, Tunis, Tunisia
  • F. Said
    Department of Internal Medicine, University Hospital of La Rabta, Tunis, Tunisia
  • A. Hamzaoui
    Department of Internal Medicine, University Hospital of La Rabta, Tunis, Tunisia
  • T. Ben Salem
    Department of Internal Medicine, University Hospital of La Rabta, Tunis, Tunisia
  • I. Ben Ghorbel
    Department of Internal Medicine, University Hospital of La Rabta, Tunis, Tunisia
  • M. Lamloum
    Department of Internal Medicine, University Hospital of La Rabta, Tunis, Tunisia
  • M.H. Houman
    Department of Internal Medicine, University Hospital of La Rabta, Tunis, Tunisia

Abstract

Adult-onset Still’s disease (AOSD) is an uncommon inflammatory condition of unknown origin. In chronic disease, joint involvement is often predominant and erosions are noted in one third of patients. Therapeutic strategies derive from observational data. Corticosteroids are usually the first-line treatment. With inadequate response to corticosteroids, methotrexate appears the best choice to control disease activity and allow for tapering of steroid use. For refractory disease, biological therapy seems the most promising. We report here the case of a 38-year-old female patient with AOSD refractory to cytotoxic agents, treated by rituximab infusion therapy with favorable outcome.

Keywords

Adult-onset Still’s disease; Treatment; Rituximab.

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Submitted: 2016-04-29 15:53:47
Published: 2016-12-16 11:20:54
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Copyright (c) 2016 N. Belfeki, M. Smiti Khanfir, F. Said, A. Hamzaoui, T. Ben Salem, I. Ben Ghorbel, M. Lamloum, M.H. Houman

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