Cover Image

Influence of TNF-α inhibition on oxidative stress of rheumatoid arthritis patients

F. Cacciapaglia, M.G. Anelli, D. Rizzo, E. Morelli, C. Scioscia, D. Mazzotta, F. Iannone, G. Lapadula
  • F. Cacciapaglia
    Internal Medicine Unit and Rheumatology Clinic, N. Melli Hospital, San Pietro Vernotico (BR), Italy | f.cacciapaglia@unicampus.it
  • M.G. Anelli
    Interdisciplinary Department of Medicine, Rheumatology Unit, Medical School, University of Bari, Italy
  • D. Rizzo
    Morelli & Di Pierro Lab, Squinzano (LE), Italy
  • E. Morelli
    Morelli & Di Pierro Lab, Squinzano (LE), Italy
  • C. Scioscia
    Interdisciplinary Department of Medicine, Rheumatology Unit, Medical School, University of Bari, Italy
  • D. Mazzotta
    Internal Medicine Unit and Rheumatology Clinic, N. Melli Hospital, San Pietro Vernotico (BR), Italy
  • F. Iannone
    Interdisciplinary Department of Medicine, Rheumatology Unit, Medical School, University of Bari, Italy
  • G. Lapadula
    Interdisciplinary Department of Medicine, Rheumatology Unit, Medical School, University of Bari, Italy

Abstract

The aim of this study was to assess circulating levels of reactive oxygen metabolites (ROMs) as a marker of oxidative stress in rheumatoid arthritis (RA) patients during an anti-tumor necrosis factor alpha (TNF-α) treatment. We enrolled 40 patients with RA (36 females; age 53±13 yrs) treated with different subcutaneously administered TNF-α inhibitors. The oxidative status was determined on the basis of plasma samples taken before, at 24 and 52 weeks of the anti-TNF-α treatment. Hydroperoxide levels were measured using the d-ROMs test, a useful clinically proven oxidative stress marker. During the anti-TNF-α therapy, we observed a significant reduction in serum ROMs levels in RA patients from 33.2±10 mg H2O2/L at baseline to 29.5±7 and 29.3±9 mg H2O2/L, at 24 and 52 weeks, respectively (p<0.05). We also identified a significant correlation between the oxidative stress status and the disease activity score on 28 joints/C-reactive protein and health assessment questionnaire disability index. The results of our study demonstrate that a good control of the disease with anti-TNF-α agents can reduce oxidative stress in RA patients. However, further studies of larger patient cohorts are needed to confirm these preliminary data.

Keywords

Anti-TNF; oxidative stress; rheumatoid arthritis; reactive oxygen species.

Full Text:

PDF
Submitted: 2015-05-19 20:49:23
Published: 2016-02-09 18:27:08
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
1029

Views:
PDF
411

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2016 F. Cacciapaglia, M.G. Anelli, D. Rizzo, E. Morelli, C. Scioscia, D. Mazzotta, F. Iannone, G. Lapadula

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 
© PAGEPress 2008-2018     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185     •     Privacy