Original Articles
Vol. 64 No. 3 (2012)
https://doi.org/10.4081/reumatismo.2012.128

The pathogenesis of the anaemia of chronic disorders

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Received: 11 November 2011
Published: 19 July 2012
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anaemia of chronic disorders, hepcidin, proinflammatory cytokines

Authors

C.U. Manzini
manzini.carlo@policlinico.mo.it
Azienda Ospedaliero-Universitaria, Modena, Italy.
E. Manzini
Azienda Ospedaliero-Universitaria, Modena, Italy.
C. Ferri
Azienda Ospedaliero-Universitaria, Modena, Italy.
Anemia of chronic disorders is a typical condition of infective, immunological and neoplastic diseases. Hepcidin and proinflammatory cytokines play a leading role in its pathogenesis. Hepcidin is a hormone produced by the liver that controls iron metabolism. It ensures that iron is retained by enterocytes (where the metal is absorbed) and by macrophages (that store the iron that results from the physiological breakdown of erythrocytes). Cytokines play a role in hepcidin synthesis, and in the proliferation and the maturation of the erythroid components within bone marrow. This paper discusses the pathogenetic mechanisms of anemia in chronic disorders.

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C.U. Manzini, Azienda Ospedaliero-Universitaria, Modena
Medicina Interna e  Specialità Mediche
E. Manzini, Azienda Ospedaliero-Universitaria, Modena
U.O.C. di Reumatologia
C. Ferri, Azienda Ospedaliero-Universitaria, Modena
U.O.C. di Reumatologia

How to Cite



1.
The pathogenesis of the anaemia of chronic disorders. Reumatismo [Internet]. 2012 Jul. 19 [cited 2026 Sep. 20];64(3):128-33. Available from: https://www.reumatismo.org/reuma/article/view/reumatismo.2012.128

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