https://doi.org/10.4081/reumatismo.2010.253

Study on the possible role of the -174G>C IL-6 promoter polymorphism in predicting response to rituximab in rheumatoid arthritis

Vol. 62 No. 4 (2010)
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Authors

M. Fabris
office@pagepress.org
L. Quartuccio
S. Lombardi
M. Benucci
M. Manfredi
M. Saracco
F. Atzeni
P. Morassi
M.A. Cimmino
E. Pontarini
C. Fabro
R. Pellerito
P. Sarzi-Puttini
M. Cutolo
A. Carletto
L.M. Bambara
F. Fischetti
F. Curcio
E. Tonutti
S. De VIta
Several studies demonstrated the efficacy of the B-cell depletion therapy with rituximab (RTX) in RA patients, including those unresponsive to anti- TNF therapy, underlying the important role of B cells in this disease (1-5). Several recent papers have demonstrated a differential effects of RTX in depleting B-cells and blocking plasma cell generation at the synovial and at the bone marrow level (7-9). This differential effect may explain why among patients who respond to RTX, some relapse while others show a very prolonged response, independently from the reappearance of B-cells in the peripheral blood (6). However, the efficacy of RTX may also depend on the individual genetic predisposition. At this regard, very few data were produced by now.

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How to Cite

Fabris, M., Quartuccio, L., Lombardi, S., Benucci, M., Manfredi, M., Saracco, M., … De VIta, S. (2010). Study on the possible role of the -174G>C IL-6 promoter polymorphism in predicting response to rituximab in rheumatoid arthritis. Reumatismo, 62(4), 253–258. https://doi.org/10.4081/reumatismo.2010.253

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