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The clinical spectrum of primary Sjögren’s syndrome: beyond exocrine glands

M.C. Leone, A. Alunno, G. Cafaro, V. Valentini, E. Marcucci, E. Bartoloni, R. Gerli
  • M.C. Leone
    Rheumatology Unit, Department of Medicine, University of Perugia, Italy
  • A. Alunno
    Rheumatology Unit, Department of Medicine, University of Perugia, Italy
  • G. Cafaro
    Rheumatology Unit, Department of Medicine, University of Perugia, Italy
  • V. Valentini
    Rheumatology Unit, Department of Medicine, University of Perugia, Italy
  • E. Marcucci
    Rheumatology Unit, Department of Medicine, University of Perugia, Italy
  • E. Bartoloni
    Rheumatology Unit, Department of Medicine, University of Perugia, Italy

Abstract

Although primary Sjögren’s syndrome (pSS) is a mild indolent chronic disease mainly characterized by mucosal dryness in the majority of cases, a consistent subgroup of patients display extra-glandular manifestations. Virtually any organs and systems can be affected, leading to a more serious disease prognosis. Therefore, the prompt identification of patients at higher risk of extra-glandular manifestations is necessary to start a thorough follow up and an aggressive treatment. The aim of this review article is to provide an overview of epidemiological, clinical and serological features of extra-glandular manifestations in pSS as well as current knowledge about putative biomarkers useful in clinical practice.

Keywords

Sjögren’s syndrome; Extra-glandular manifestations; Cardiovascular risk.

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Submitted: 2017-06-20 07:44:43
Published: 2017-09-21 12:06:23
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Copyright (c) 2017 M.C. Leone, A. Alunno, G. Cafaro, V. Valentini, E. Marcucci, E. Bartoloni, R. Gerli

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